Magalie Lalanne Selected Research

Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)

11/2020	Iron chelation rescues hemolytic anemia and skin photosensitivity in congenital erythropoietic porphyria.
1/2017	Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition.
11/2013	Therapeutic potential of proteasome inhibitors in congenital erythropoietic porphyria.
7/2012	Metabolic correction of congenital erythropoietic porphyria with iPSCs free of reprogramming factors.
8/2010	Modeling of congenital erythropoietic porphyria by RNA interference: a new tool for preclinical gene therapy evaluation.
1/2008	Effective gene therapy of mice with congenital erythropoietic porphyria is facilitated by a survival advantage of corrected erythroid cells.

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Magalie Lalanne Research Topics

Disease

9	Erythropoietic Porphyria (Congenital Erythropoietic Porphyria) 11/2020 - 01/2008
5	Hemolytic Anemia 11/2020 - 07/2012
2	Hemolysis 11/2020 - 12/2019
2	Iron Overload 11/2020 - 12/2019
2	Anemia 11/2020 - 12/2019
2	Primary hyperoxaluria type 1 10/2019 - 01/2019
2	Erythropoietic Protoporphyria 07/2011 - 09/2003
1	Porphyrias (Porphyria) 01/2020
1	Congenital Hemolytic Anemia (Hemolytic Anemia, Congenital) 12/2019
1	Urolithiasis 10/2019
1	Nephrocalcinosis 10/2019
1	Renal Insufficiency (Renal Failure) 10/2019
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2019
1	Liver Diseases (Liver Disease) 07/2011
1	Liver Cirrhosis (Hepatic Cirrhosis) 07/2011
1	Liver Failure 07/2011
1	Hepatitis 01/2003

Drug/Important Bio-Agent (IBA)

6	Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA 11/2020 - 01/2008
6	Heme (Haem)IBA 11/2020 - 09/2003
5	PorphyrinsIBA 11/2020 - 07/2012
5	EnzymesIBA 10/2019 - 09/2003
2	IronIBA 11/2020 - 12/2019
2	OxalatesIBA 10/2019 - 01/2019
2	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 10/2019 - 01/2019
2	Proteasome InhibitorsIBA 01/2017 - 11/2013
2	protoporphyrin IXIBA 07/2011 - 09/2003
1	DeferiproneIBA 11/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	HepcidinsIBA 12/2019
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2019
1	CalciumIBA 01/2019
1	Calcium OxalateIBA 01/2019
1	SaltsIBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	Busulfan (Busulfex)FDA Link 07/2011
1	Ferrochelatase (Heme Synthetase)IBA 09/2003
1	enhanced green fluorescent proteinIBA 01/2003
1	ElementsIBA 01/2003
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2003

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/2011